| 口服绿茶多酚对离体心脏的保护作用 |
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| 引用本文： | 高文波,朱有华,王亚伟.口服绿茶多酚对离体心脏的保护作用[J].实用医学杂志,2006,22(12):1362-1363. |
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| 作者姓名： | 高文波 朱有华 王亚伟 |
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| 作者单位： | 200003,上海市,第二军医大学附属长征医院器官移植研究所 |
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| 摘 要： | 目的:探讨口服绿茶多酚对离体心脏的保护作用。方法:16只SD大鼠,随机分为两组,实验组每天经胃管灌服5%绿茶多酚溶液40mL,对照组灌服生理盐水,20d后分别摘取心脏行离体灌注(Langendorff模型),测定心功能,然后灌注并保存于4℃UW保存液中,8h后取出,再行Langendorff灌注,再次测定心功能参数。测定再灌注后冠脉流出液中的乳酸脱氢酶(LDH)、肌酸激酶(CK)活性,心肌组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量;观察心肌超微结构。结果:除心率外,实验组各项心功能参数均优于对照组(P<0.05),心肌含水量、MDA低于对照组(P<0.05),冠脉流出量、心肌组织中SOD活性优于对照组(P<0.05),冠脉流出液中LDH、CK活性低于对照组(P<0.05);实验组心肌超微结构的损伤较对照组显著减轻。结论:口服绿茶多酚对大鼠离体心脏具有保护作用。
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| 关 键 词： | 茶 酚类 心脏 保存 |
| 收稿时间： | 2006-02-07 |
| 修稿时间： | 2006-02-07 |
Effects of oral green tea polyphenols on the preservation of isolated rat heart |
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| GAO Wen-bo,ZHU You-hua,WANG Ya-wei.Effects of oral green tea polyphenols on the preservation of isolated rat heart[J].The Journal of Practical Medicine,2006,22(12):1362-1363. |
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| Authors: | GAO Wen-bo ZHU You-hua WANG Ya-wei |
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| Institution: | Institute of Organ Transplantation, Shanghai Changzheng Hospital, Shanghai 200003, China |
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| Abstract: | Objective To investigate the effects of oral green tea polyphenols (GTP) on the preservation of isolated rat heart. Methods Sixteen SD rats were randomly divided into 2 groups. 8 rats in the experimental group were orally administered with GTP for 20 days while 8 rats in the control group received saline solution. The rat hearts were removed and performed with Langendorff perfusion, and the cardiac function was measured. The isolated hearts were then stored in UW solutions at 4℃ for 8 hours. The cardiac fun... |
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| Keywords: | Tea Phenols Heart Preservation |
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