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Membranoproliferative glomerulonephritis in a girl and her mother |
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| Authors: | Osamu Motoyama Ken Sakai Yasushi Ohashi Sonoo Mizuiri Tsutomu Hatori Kikuo Iitaka Yasushi Koitabashi |
| Affiliation: | (1) Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan;(2) Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan;(3) Department of Pathology, Toho University Medical Center, Omori Hospital, Tokyo, Japan;(4) Department of Pediatrics, Social Insurance Sagamino Hospital, Kanagawa, Japan;(5) Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan |
| Abstract: | A girl and her mother were diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I. Microscopic hematuria and proteinuria presented at 9 years of age in the mother and at 14 years in the daughter. Both had persistent hypocomplementemia and were treated with steroids. When the mother was 40 years old, proteinuria was still continuing and creatinine clearance was 64.4 ml/min per 1.73 m2. When the daughter was 15 years old, microscopic hematuria was still continuing. To our knowledge, familial cases of MPGN in two generations have not been reported in Japan. |
| Keywords: | Familial case Membranoproliferative glomerulonephritis |
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