| 病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达 |
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| 引用本文： | 伍成奇,刘林嶓,李珊珊,陈言汤,牛扶幼,郝媛媛. 病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达[J]. 郑州大学学报(医学版), 2006, 41(6): 1038-1041 |
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| 作者姓名： | 伍成奇 刘林嶓 李珊珊 陈言汤 牛扶幼 郝媛媛 |
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| 作者单位： | 郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州,450052;南阳市中心医院整形外科,南阳,473000;郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州,450052;郑州大学基础医学院病理学教研室郑州450052 |
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| 摘 要： | 目的:检测病理性瘢痕组织中Survivin、P33ING1、Caspase-3蛋白的表达情况.方法:采用免疫组织化学方法检测30例病理性瘢痕组织、10例非病理性瘢痕和20例正常皮肤组织中Survivin、P33ING1、Caspase-3的表达情况.结果:病理性瘢痕、非病理性瘢痕和正常皮肤组织中Survivin、P33ING1和Caspase-3的阳性表达率分别为80.0%、50.0%、35.0%,43.3%、70.0%、85.0%和30.0%、80.0%、90.0%;病理性瘢痕组织与非病理性瘢痕和正常皮肤组织比较,3指标差异均有统计学意义(P＜0.05).病理性瘢痕组织中Caspase-3与Survivin(r=-0.400)和P33ING1(r=0.602)表达均具有相关性(P＜0.05).结论:Survivin的高表达与Caspase-3和P33ING1的表达下调在病理性瘢痕的形成中可能起协同作用.
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| 关 键 词： | 增生性瘢痕 瘢痕疙瘩 Survivin P33ING1 Caspase-3 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2005-11-15 |
Expression of Survivin, P33ING1, and Caspase-3 proteins in pathologic scar tissue |
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| WU Chengqi,LIU Linbo,LI Shanshan,CHEN Yantang,NIU Fuyou,HAO Yuanyuan. Expression of Survivin, P33ING1, and Caspase-3 proteins in pathologic scar tissue[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(6): 1038-1041 |
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| Authors: | WU Chengqi LIU Linbo LI Shanshan CHEN Yantang NIU Fuyou HAO Yuanyuan |
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| Affiliation: | 1. Department of Plastic Surgery, the First Affiliated Hospital, Zhengzhou University ; Henan Key Laboratory of Clinical Medicine, Zhengzhou 450052 ;2. Department of Plastic Surgery, Nanyang Central Hospital, Nanyang 473000; 3. Department of Pathology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the expressions of apoptosis-related Survivin, P33ING1, and Caspase-3 in pathologic scar formation.Methods: The expressions of Survivin, P33ING1, and Caspase-3 in 30 cases of pathologic scar, 10 cases of non-pathologic scars, and 20 cases of normal skin tissue were detected using immunohistochemical methods.Results: The positive rates of survivin, P33ING1, and Caspase-3 in pathologic scar, non-pathologic scar, and normal skin tissue were 80.0%,50.0%,35.0%,43.3%,70.0%,85.0% and 30.0%,80.0%,90.0%, respectively.Compared with non-pathologic scar and normal skin cases,the expressions of Survivin,P33ING1, and Caspase-3 had significant difference in pathologic scar cases(P<0.05). Caspase-3 expression were correlated with Survivin (r=-0.400) and P33ING1 (r= 0.602 ) in pathologic scar tissue (P<0.05). Conclusion: The overexpression of Survivin and down-regulation of Caspase-3 and P33ING1 expressions may play a coordinated role in pathologic scars. |
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| Keywords: | hypertrophic scar keloid Survivin P33ING1 Caspase-3 |
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