| 左旋精氨酸在急性胰腺炎治疗中的剂量效应 |
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| 引用本文： | 李广阔,张肇达,刘续宝,郭月瑜,田伏洲.左旋精氨酸在急性胰腺炎治疗中的剂量效应[J].西南国防医药,1999(5). |
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| 作者姓名： | 李广阔 张肇达 刘续宝 郭月瑜 田伏洲 |
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| 作者单位： | 成都军区总医院外二科，华西医科大学附一院普外科，华西医科大学附一院普外科，华西医科大学附一院肾病科，成都军区总医院外二科 成都 610083，成都 610041，成都 610041，成都 610083 |
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| 摘 要： | 目的:探讨左旋精氨酸(L-Arg)在急性胰腺炎治疗中的剂量效应。方法:观察不同剂量L-Arg治疗急性水肿性胰腺炎(AEP)大鼠后,血浆和胰组织一氧化氮(NO)浓度、血浆淀粉酶、平均动脉压(MAP)、胰组织病理等的变化。结果:(1)AEP大鼠血浆、胰组织NO浓度明显降低,小剂量L-Arg(50mg,100mg/kg)升高了血浆、胰组织NO浓度,改善了大鼠AEP;随着L—Arg剂量的增加,达800mg、1600mg/kg时,血浆、胰组织NO浓度过度升高,加重AEP成为急性出血坏死性胰腺炎(AHNP),且以80mg/kg组最明显;(2)实验所用的L—Arg对MAP的影响较小。结论:L—Arg的作用机理与NO的生物学行为有密切关系,临床应用L-Arg治疗急性胰腺炎应注意其类似NO的“双刃性”,尤其大剂量应用要慎重。
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| 关 键 词： | 急性胰腺炎 平均动脉压 左旋精氨酸 一氧化氮 |
DOSE-DEPENDENT ROLE OF L-ARGININE IN TREATMENT OF ACUTE PANCREATITIS IN RATS |
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| Li Guangkuo,Zhang Zhaoda,Liu Xubao,Guo Yueyu,Tian Fuzhou Center of General Surgery of PLA,General Hospital of Chengdu Military Command,Chengdu, First Affiliated Hospital of West China University of Medical Sciences,Chengdu,..DOSE-DEPENDENT ROLE OF L-ARGININE IN TREATMENT OF ACUTE PANCREATITIS IN RATS[J].Medical Journal of National Defending forces in Southwest China,1999(5). |
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| Authors: | Li Guangkuo Zhang Zhaoda Liu Xubao Guo Yueyu Tian Fuzhou Center of General Surgery of PLA General Hospital of Chengdu Military Command Chengdu First Affiliated Hospital of West China University of Medical Sciences Chengdu |
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| Institution: | Li Guangkuo,Zhang Zhaoda,Liu Xubao,Guo Yueyu,Tian Fuzhou Center of General Surgery of PLA,General Hospital of Chengdu Military Command,Chengdu,610083, First Affiliated Hospital of West China University of Medical Sciences,Chengdu,610041. |
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| Abstract: | |
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| Keywords: | acute pancreatitis treatment L-arginine dose-dependent effect |
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