An immunohistochemical study of oral lichen planus |
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| Authors: | P D Toto H T Nadimi |
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| Affiliation: | 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Epidemiology and Biostatistics, Faculty of Health, Qom University of Medical Sciences, Qom, Iran;3. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran;5. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran;1. Department of Molecular and Translational Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland;2. Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland;3. Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland;4. Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland;5. Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland;6. Department of Neurosurgery, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland;1. National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan;2. Department of Otolaryngology, Head and Neck Collaborative Oncology Group, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;3. Genomics Research Center, Academia Sinica, Taipei, Taiwan;4. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan;5. Department of Internal Medicine, Division of Hematology and Oncology, National Cheng Kung University Hospital, College of Medical, National Cheng Kung University, Tainan, Taiwan;6. Department of Life Sciences, National Central University, Taoyuan, Taiwan;1. Department of Computer Science, Ariel University, Ariel 40700, Israel;2. School of Mathematics, Tel Aviv University, Tel Aviv 69978, Israel;1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India;2. Department of Obstetricsand Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India |
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| Abstract: | Specimens from 22 cases of oral lichen planus were prepared for studies of the basement membrane zone by immunohistochemical and histochemical methods. Langerhans' cells, monocytes, and lymphocytes constitute the predominant cells of the inflammatory infiltrate, thus indicating a cell-mediated response. Lymphocyte-related necrosis of epithelium and nonspecific vasculitis are associated with an altered basement membrane zone. Immunoproteins, including IgG, IgA, IgM, and C'3 as well as fibrinogen, are present and distributed in a nonspecific pattern. |
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