抗幽门螺杆菌治疗对急性脑梗死患者血清炎性因子的影响

目的探讨抗幽门螺旋杆菌治疗对脑梗死患者血清中炎症因子(TNF-α、CRP、Fib)水平的影响,为脑血管病的治疗提供新依据。方法选取2012年1月至2012年8月我院收治的HP-IgG(+)性的急性脑梗死患者88例,随机分为治疗组和非治疗组。另选取HP-IgG(-)性的急性脑梗死患者45例为对照组。非治疗组与对照组仅给予常规治疗,治疗组在常规治疗同时给予阿莫西林,测定治疗前后各组脑梗死患者血清中TNF-α、CRP、Fib的含量。结果治疗组抗幽门螺旋杆菌治疗后,血清中TNF-α、CRP、Fib的含量分别为(6.57±0.58)mg/L、(5.63±0.72)ng/mL、(5.09±0.48)g/L,显著低于非治疗组,差异有统计学意义(P0.05)。结论 Hp感染是脑梗死的重要危险因素,抗幽门螺旋杆菌治疗能降低脑梗死患者血清中炎症因子(TNF-α、CRP、Fib)水平。

Influence of Anti -Helicobacter pylori therapy on serum levels of inflammatory factors in acute cerebral infarction

Objective To explore the influence of anti - Helicobacter pylori （Hp） therapy on serum level of inflammatory factors （TNF-α, CRP, Fib）in acute cerebral infarction, so as to provide a new basis for the eontrol of cerebrovaacular diseases. Methods From January 2012 to August 2012, 88 cases of acute cerebral infarction with HP- IgG（ ± ）treated in our hospital were divided into two groups ： treatment group and non - treatment group. 45 cases of acute cerebral infarc- tion with HP - IgG（ - ） were selected as control group. All groups were detected for serum levels of TNF - α, CRP and Fib before and after treatment. Results Serum levels of TNF - ct, CRP and Fib were 6.57 ± 0.58） rag/L, （5.63 ± 0.72） rig/ mL and（5.09 ± 0.48）g/L respectively in treatment group, which were significantly lower than those in non -treatment group （P 〈 0.05）. Conclusions Hp infection is an important risk factor for cerebral infarction, and anti - Helicobacter Dvlori therapy can lower serum levels of inflammatory factors（TNF- α. CRP, Fib）.