多塞平对支气管哮喘患者焦虑、抑郁情绪治疗效果观察

目的观察多塞平对支气管哮喘患者焦虑、抑郁情绪的治疗效果。方法选择2010年1月—2012年12月收治的支气管哮喘伴焦虑、抑郁情绪患者71例,随机分为对照组35例和观察组36例。对照组使用常规治疗方法。观察组在对照组的基础上使用多塞平,开始25 mg/次,2~3次/d,以后逐渐增加至总量100~250 mg/d,最大用量不超过300 mg/d。计量资料采用t检验,计数资料采用χ2检验,P0.05为差异有统计学意义。结果治疗后,对照组焦虑和抑郁评分分别为(66.3±5.7)、(63.8±5.3)分,观察组分别为(45.5±2.8)、(43.1±4.0)分,两组比较差异均有统计学意义(t=19.600、18.610,均P0.05)。治疗后,对照组肺功能方面FVC、FEV1/预计值、FEV1/FVC及MVV分别为(3.3±0.2)L、(55.8±8.5)%、(60.3±8.9)%、(48.6±4.1)%,观察组分别为(3.9±0.5)L、(73.2±12.2)%、(78.1±13.3)%、(57.5±6.5)%,两组比较差异均有统计学意义(t=6.603、6.954、6.608、6.878,均P0.05)。对照组控制良好12例,基本控制14例,未控制9例,控制率74.3%;观察组控制良好23例,基本控制11例,未控制2例,控制率94.4%。两组控制率比较差异有统计学意义(χ2=5.508,P0.05)。结论多塞平具有起效快、基本无不良反应等优点,能有效减少患者的焦虑和抑郁情绪,提高治疗效果,且临床治疗剂量小,作用时间长,药物价格低廉,值得临床推广应用。

Clinical observation on doxepin for anxiety and depression in patients with bronchial asthma

Objective To investigate the effect of doxepin for depression and anxiety in patients with bronchial asthma anxiety. Methods From January 2010 to December 2012,71 cases of bronchial asthma with anxiety and depression treated in our hospi-tal were selected.They were randomly divided into control group（n=35） and observation group（n=36）.Control group received con-ventional treatment,while observation group received doxepin in addition,which started with the dose of 25 rag,2-3 times/d,then gradually increased to a total of 100-250 mg/d,with the maximum amount not exceeding 300 mg/d.Measurement data were pro-cessed by t-test,and count data byX^2 test,P〈0.05 was Considered as statistically significant.Results After treatment,score of anx-iety and depression was （66.3 ± 5.7） points and （63.8 ± 5.3） points respectively in control group,and （45.5 ± 2.8） and （43.1 ± 4.0） points respectively in observation group,the difference was statistically significance（t=19.600,18.610,P〈0.05）.After treatment, in terms of lung function,FVC,FEV1/predicted ,FEV1/FVC and MVV were （3.3 ± 0.2）L,（55.8 ± 8.5）%,（60.3 ± 8.9）% and （48.6 ± 4.1）% respectively in control group,while they were （3.9 ± 0.5） L,（73.2 ± 12.2）%,（78.1 ± 13.3）%,（57.5 ± 6.5）% respectively in ob-servation group,the difference was statistically significant（t=6.603,6.954,6.608,6.878,P〈0.05）.In control group,symptoms of anxiety and depression were successfully controlled in 12 cases,basically controlled in 14 cases,uncontrolled in 9 cases,the rate of disease control was 74.3%.In observation group,symptoms of anxiety and depression were successfully controlled in 23 cases,basically controlled in 11 cases,uncontrolled in 2 cases,the rate of disease control was 94.4%（X^2=5.508,P〈0.05）.Conclusion Doxepin is of rapid onset and few adverse reactions,it can effectively reduce anxiety and depression in patients with bronchial asthma and im-prove clinical outcomes,with small doses,long action and low price,therefore,it is worthy of clinical application.