Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery |
| |
Authors: | Laura Hocum Stone Tammy A. Butterick Cayla Duffy Corey Swingen Herbert B. Ward Rosemary F. Kelly Edward O. McFalls |
| |
Affiliation: | 1.Department of Surgery,University of Minnesota,Minneapolis,USA;2.Research Minneapolis VAHCS,Minneapolis,USA;3.Department of Food Science and Nutrition,University of Minnesota,Minneapolis,USA;4.University of Minnesota Nutrition and Obesity Center,Minneapolis,USA;5.Cardiology (111C),VA Medical Center,Minneapolis,USA |
| |
Abstract: | There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo. At 4-week post-CABG, circumferential strain measurements in the hibernating LAD region from placebo and CoQ10 groups were not different and increased to a similar extent with dobutamine (?14.7?±?0.6 versus ?14.8?±?0.1, respectively (NS)). Post-sacrifice, oxidant stress markers were obtained in the mitochondrial isolates and protein carbonyl in the placebo, and CoQ10 groups were 6.14?±?0.36 and 5.05?±?0.32 nmol/mg, respectively (NS). In summary, CoQ10 did not improve contractile reserve or reduce oxidant stress at 4-week post-CABG. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|