| 豚鼠哮喘模型血和支气管肺泡灌洗液中IL—6水平及地塞米松的影响 |
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| 引用本文： | 潘频华,吴鄂生,陈清兰,尹本义,胡成平.豚鼠哮喘模型血和支气管肺泡灌洗液中IL—6水平及地塞米松的影响[J].中国现代医学杂志,2001,11(4):28-29. |
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| 作者姓名： | 潘频华 吴鄂生 陈清兰 尹本义 胡成平 |
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| 作者单位： | 湖南医科大学附属湘雅医院呼吸内科 |
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| 摘 要： | 目的应用放免法查测豚鼠过敏性哮喘模型外周血和支气管肺泡灌洗液(BALF)白细胞介素(IL-6)水平，并探讨其与支气管肺泡灌洗液中炎症细胞的相关性。结果发现外周血IL-6水平在哮喘组、地塞米松组、正常对照组之间无明显差异，而在BALF中IL-6水平哮喘组106.46±65.58pg/ml，显著高于正常对照组和地塞米松组，差异有显著性(P<0.05和P<0.01)，但哮喘组BALF中IL-6水平与嗜酸性细胞百分率之间无相关性(r=0.1508P>0.05)。结论IL-6参与了哮喘发病机制的调节。
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| 关 键 词： | 支气管哮喘 白细胞介素 支气管肺泡灌洗 豚鼠 治疗 |
| 修稿时间： | 1999年6月18日 |
THE IL-6 LEVEL IN THE BLOOD AND
BRONCHAL ALVEOLAR LAVAGE FLUID(BALF)OF ASTHMATIC GUNIEA- PIGS
AND THE INFLUENCE OF DEXAMTHASONE |
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| Pan Pinhua,Wu Eshen,Cheng Qinlan,Yin Beyi,Hu Chengping.THE IL-6 LEVEL IN THE BLOOD AND
BRONCHAL ALVEOLAR LAVAGE FLUID(BALF)OF ASTHMATIC GUNIEA- PIGS
AND THE INFLUENCE OF DEXAMTHASONE[J].China Journal of Modern Medicine,2001,11(4):28-29. |
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| Authors: | Pan Pinhua Wu Eshen Cheng Qinlan Yin Beyi Hu Chengping |
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| Institution: | Pan Pinhua,Wu Eshen,Cheng Qinlan,Yin Beyi,Hu Chengping Department of Respiratory Medicine,Xiang Ya Hospita,Zhongnan University,Changsha,410008[ |
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| Abstract: | Objective:To investigate the level of IL-6 in the blood and BALF of asthmatic guniea pigs and the effect of dexamethasone.Methods:Guniea-pigs were divided into 3 groups:asthma group,dexamethasone-treatedgroup and control group,The IL-6 was detected by RLA.Results:The eosinophil (Eos) percentage in BALF of asthmatic group was higher than other two groups,The IL-6 level in blood has no difference in three groups.The IL-6 level in BALF of asthmatic group was higher than dexamethasone-treated group and control group,there were no diffecence in BALF IL-6 level between dexamathasone-treated group and control group.In asthma group,there were no relation between BALF IL-6 level and the Eos percentage.Conclusions:IL-6 may be involved in the development of allergic asthma. |
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| Keywords: | Bronchial Asthma Interlenkins BALF Guniea- pigs |
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