Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia |
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| Authors: | Amanda L. Winter Heather M. Conklin Vida L. Tyc Heather Stancel Pamela S. Hinds Melissa M. Hudson |
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| Affiliation: | 1. Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, TX, USA;2. Department of Psychology, St. Jude Children’s Research Hospital, Memphis, TN, USA;3. Department of Nursing Research and Quality Outcomes, Children’s National Health Systems, Washington, DC, USA;4. Department of Pediatrics, George Washington University, Washington, DC, USA;5. Department of Oncology, Division of Cancer Survivorship, St. Jude Children’s Research Hospital, Memphis, TN, USA |
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| Abstract: | Background: Survivors of pediatric brain tumors (BT) and acute lymphoblastic leukemia (ALL) are at risk for neurocognitive late effects related to executive function. Procedure: Survivors of BT (48) and ALL (50) completed neurocognitive assessment. Executive function was compared to estimated IQ and population norms by diagnostic group. Results: Both BT and ALL demonstrated relative executive function weaknesses. As a group, BT survivors demonstrated weaker executive functioning than expected for age. Those BT survivors with deficits exhibited a profile suggestive of global executive dysfunction, while affected ALL survivors tended to demonstrate specific rapid naming deficits. Conclusion: Findings suggest that pediatric BT and ALL survivors may exhibit different profiles of executive function late effects, which may necessitate distinct intervention plans. |
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| Keywords: | Pediatric Leukemia Brain tumor Executive function Late effects |
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