New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio |
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Authors: | Mustafa Oylumlu Ali Ozler Abdulkadir Yildiz Muhammed Oylumlu Halit Acet Nihat Polat |
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Affiliation: | 1. Department of Cardiologydr.oylumlu@yahoo.com;3. Department of Obstetrics and Gynecology, Dicle University School of MedicineDiyarbak?rTurkey;4. Department of Cardiology;5. Department of Cardiology, Dumlupinar University School of MedicineKutahyaTurkey |
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Abstract: | Background: Increased epicardial fat thickness (EFT) has been proposed as a new cardiometabolic risk factor. The neutrophil/lymphocyte ratio (NLR) has predictive and prognostic value in several cardiovascular diseases. The aim of this study was to explore the association between EFT and NLR in patients with pre-eclampsia.Methods: Hundred and eight pregnant patients with a mean age of 30.6?±?6.3 years were included in the study. Patients were divided into two groups based on the presence of pre-eclampsia. All participants underwent transthoracic echocardiography imaging, and complete blood counts were measured by an automated hematology analyzer. Statistical analysis was performed using the Chi-square, Mann–Whitney U, correlation and logistic regression tests, and receiver operating characteristic (ROC) analysis.Result: The mean EFT value of the pre-eclampsia group was significantly higher than the control group (6.9?±?0.6 versus 5.6?±?0.6; p?0.001), and the NLR value of the pre-eclampsia group was also significantly higher than the control group (7.3?±?3.5 versus 3.1?±?1.1; p?0.001). Multivariate analysis showed that increased levels of NLR and echocardiographic EFT are independent predictors of pre-eclampsia. In the receiver operating characteristic analysis, a level of EFT ≥ 6.2?mm and NLR ≥ 4.1 predicted the presence of pre-eclampsia with 77.8% sensitivity, 79.6% specificity and 83.3% sensitivity, 81.5% specificity, respectively.Conclusion: Unlike many other inflammatory markers and bioassays, NLR and echocardiographic EFT are inexpensive and readily available biomarkers that may be useful for risk stratification in patients with pre-eclampsia. |
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Keywords: | Echocardiography epicardial fat thickness hypertension neutrophil to lymphocyte ratio pre-eclampsia |
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