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Gonadotroph adenoma causing ovarian hyperstimulation syndrome in a premenopausal woman |
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| Authors: | Jowita Halupczok Bożena Bidzińska-Speichert Agnieszka Lenarcik-Kabza Grzegorz Zieliński Alicja Filus Maria Maksymowicz |
| Affiliation: | 1. Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical UniversityWroclawPolandjowita16@op.pl;3. Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical UniversityWroclawPoland;4. Department of Neurosurgery, Military Institute of MedicineWarsawPoland;5. Department of Pathology, Maria Sk?odowska-Curie Memorial Cancer Center and Institute of OncologyWarsawPoland |
| Abstract: | Introduction: Gonadotroph adenomas occur commonly in middle-aged adults without any specific endocrinological symptoms. To date, only 30 cases of gonadotropinoma causing ovarian hyperstimulation syndrome in pre-menopausal women have been reported. Case report: A 37-year old woman with pituitary macroadenoma and hyperprolactinaemia was admitted to the Department of Endocrinology, Diabetology and Isotope Therapy. She presented with recurrent ovarian cysts, menstrual disturbances, headaches, visual impairment and galactorrhea. Her endocrine profile showed normal values of FSH, elevated concentrations of estradiol and suppressed LH levels. Transsphenoidal resection of the tumor tissue resulted in normalization of the hormone values and improvement in the clinical picture. Conclusions: Gonadotroph adenomas should be considered in the differential diagnosis in premenopausal women with OHSS. |
| Keywords: | α-Subunit estradiol gonadotroph adenoma follicle-stimulating hormone luteinizing hormone ovarian hyperstimulation syndrome |