The pre-transplant anemic condition is independent of long-term outcome in living-related kidney transplantation |
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Authors: | Turun Song Li Wang Shaofeng He Lei Fu Zhongli Huang Qiang Wei |
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Affiliation: | Department of Urology, West China Hospital, Sichuan UniversityChengdu, SichuanPeople’s Republic of China |
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Abstract: | The relationship between pre-transplant Hemoglobin (Hb) concentration and long-term outcome of living-related kidney transplantation is far from well addressed. A retrospective cohort study was conducted by reviewing the medical profile of the patients who received living-related kidney transplantations at our center from January 2006 to January 2013. Patients were divided into two groups: high Hb group (≥10?g/dL) and low Hb group (<10?g/dL). Cox regression model was utilized to analyze the effect of pre-transplant hemoglobin concentration on the patient and graft survival. About 422 patients were of Hb level <10?g/dL (78.30?±?14.18?g/dL), 280 were >10?g/dL (116.2?±?14.43?g/dL) (p?0.001). In a follow-up of 35.34?±?18.12 months, we did not find any difference in serum creatinine between the two groups. Low Hb concentration is not associated with increased risk of developing DGF (HR?=?1.186, 95% CI: 0.53–2.654), acute rejection (HR?=?1.338, 95% CI: 0.919–1.947), overall infection (HR?=?1.263, 95% CI: 0.847–1.885) nor perioperational infection (HR?=?1.019, 95% CI: 0.513–2.026). Though we detected a trend that low Hb level group were of higher incidence of patient death and graft failure, the two groups did not differ significantly (2.38% vs. 0.71%, p?=?0.096; and 4.04% vs. 2.14%, p?=?0.165, respectively). Cox regression model revealed that pre-transplant Hb level <10?g/dL was independent of increased overall mortality (HR?=?3.379; 95% CI: 0.706–17.172) and increased death censored allograft failure risk (HR?=?1.556; 95% CI: 0.595–4.069). Pre-transplant Hb concentration <10?g/dL is independent of poor long-term outcome of living-related kidney transplantation. |
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Keywords: | Graft failure hemoglobin concentration living-related kidney transplantation patient survival rejection |
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