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Monoterpenoids from the whole herb of Veronicastrum axillare |
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| Authors: | Xue-Hong Deng Fan-Fu Fang Yu Wu |
| Institution: | 1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University ShanghaiPR China;2. Department of Pharmacy, Fujian University of Traditional Chinese Medicine FuzhouPR China;3. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University ShanghaiPR China |
| Abstract: | Context: Veronicastrum axillare (Sieb. et Zucc.) Yamazaki (Scrophulariaceae) embraces varieties of bioactivities such as anti-inflammatory, anti-pyresis and detoxification activity, while little is known of the phytochemical components of this medicinal plant. Objective: To isolate and identify bioactive constituents from the whole herb of V. axillare. Materials and methods: Ethanol extract of the whole herb of V. axillare was subjected to successive column chromatography. Chemical structures of the compounds were elucidated by detailed spectroscopic analyses on the basis of NMR, IR and HR-MS data. Results: A new monoterpenoid, axillacetal A (1) and a known analogue, tarumal (2), were isolated from the whole herb of V. axillare. The structure of tarumal (2) was also revised according to our NMR data. Discussion and conclusion: This is the first report on the isolation and authentication of novel chemical constituents from V. axillare. |
| Keywords: | Axillacetal A monoterpenoids tarumal Veronicastrum axillare |