Maternal,placental and fetal exposure to bisphenol A in women with and without preeclampsia |
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| Authors: | François Leclerc Marie-France Dubois |
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| Affiliation: | 1. Department of Obstetrics and Gynecology;2. Department of Community Health Sciences, Faculty of Medicine and Health Sciences, Centre Hospitalier Universitaire de Sherbrooke (CHUS), Université de SherbrookeSherbrooke, QuebecCanada |
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| Abstract: | Objectives: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. Methods: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography–mass spectrometry (GC-MS) method. Results: BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown. Conclusions: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta. |
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| Keywords: | Bisphenol A Fetal blood Maternal blood Placenta Preeclampsia. |
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