| 豚鼠肺切除术后咳嗽模型建立及针刺肺经对其血清PGE-2、BK的影响 |
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| 引用本文： | 祝永福,解明然,周美启.豚鼠肺切除术后咳嗽模型建立及针刺肺经对其血清PGE-2、BK的影响[J].中医药临床杂志,2019,31(2):294-297. |
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| 作者姓名： | 祝永福 解明然 周美启 |
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| 作者单位： | 安徽中医药大学研究生院 安徽合肥230038;安徽中医药大学第一附属医院 安徽合肥230038;中国科学技术大学附属第一医院胸外科 安徽合肥230038;安徽中医药科学院亳州中医药研究所 安徽亳州 236800 |
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| 基金项目： | 国家重点研发计划;安徽高校科研创新平台团队建设项目;安徽中医药大学探索性科研项目 |
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| 摘 要： | 目的 :建立豚鼠肺切除术后咳嗽模型并进行初步评价。方法:应用50只豚鼠进行肺部手术切除并结合支气管激发咳嗽实验方法构建肺切除术后咳嗽动物模型,给予针刺干预观察豚鼠咳嗽变化结果,治疗前后测定豚鼠血浆前列腺素E-2(PGE-2)、缓激肽(BK)数值变化,以及豚鼠肺组织免疫组化形态学观察。结果:针刺治疗前后针刺肺经组BK、PGE-2出现明显变化(P<0.01),与针刺非经非穴组、模型组相比,亦具有明显统计学差异(P<0.01)。结论:成功建立了豚鼠肺切除术后咳嗽模型,针刺肺经有助于缓解豚鼠肺切除术后咳嗽,同时PGE2和BK测定出现明显改变(与针刺非经非穴组、模型组相比,P<0.01),豚鼠肺组织免疫组化形态学观察也有明显改变。
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| 关 键 词： | 针灸 肺切除术 咳嗽 |
Establishment of Cough Model after Guinea Pig Lung Resection and the Effect of Acupuncture Lung Meridian on its Serum of PGE-2 and BK |
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| Zhu Yongfu,Xie Mingran,Zhou Meiqi.Establishment of Cough Model after Guinea Pig Lung Resection and the Effect of Acupuncture Lung Meridian on its Serum of PGE-2 and BK[J].Clinical journal of traditional chinese medicine,2019,31(2):294-297. |
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| Authors: | Zhu Yongfu Xie Mingran Zhou Meiqi |
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| Institution: | (Graduate School of Anhui University of Chinese Medicine,Hefei 230038,China;The First Department of Oncology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230038,China;Department of Thoracic Surgery,The First Affiliated Hospital,University of Science and Technology of China,Hefei 230038,China;Bozhou Research Institute of Chinese Medicine,Anhui Academy of Chinese Medicine,Bozhou 236800,China) |
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| Abstract: | Zhu Yongfu;Xie Mingran;Zhou Meiqi(Graduate School of Anhui University of Chinese Medicine,Hefei 230038,China;The First Department of Oncology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230038,China;Department of Thoracic Surgery,The First Affiliated Hospital,University of Science and Technology of China,Hefei 230038,China;Bozhou Research Institute of Chinese Medicine,Anhui Academy of Chinese Medicine,Bozhou 236800,China) |
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| Keywords: | Acupuncture Lung resection Cough |
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