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Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: Evidence from a systematic review |
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| Authors: | Lisa-Jane Keegan Rosa Reed-Berendt Elizabeth Neilly Deborah Murdoch-Eaton |
| Affiliation: | 1. Programme in Clinical Psychology, Leeds Institute of Health Sciences, University of Leeds,Clarendon Road, Leeds LS2 9LJ, UK;2. Paediatric Neuropsychology Service, The Leeds Teaching Hospitals NHS Trust,E Floor, Martin Wing, Leeds General Infirmary, Leeds LS1 3EX, UK;3. Health Sciences Library, University of Leeds,Leeds LS2 9JT, UK;4. Department of Paediatric Neurology, The Leeds Teaching Hospitals NHS Trust,F Floor, Martin Wing, Leeds General Infirmary, Leeds LS1 3EX, UK |
| Abstract: | Objective: To retrieve and review all the relevant literature describing the administration of melatonin to treat impaired sleep in children following acquired brain injury (ABI). Methods: A systematic search and retrieval of the literature was conducted using advanced search techniques. The retrieval identified 589 papers, seven of which were relevant. Review/outcomes criteria were developed and study quality was determined. Results: There is paucity of high-quality evidence to support use of melatonin for sleep impairment post paediatric ABI. Variation in dosage, screening and outcome measures, data reporting and a lack of impairment delineation and treatment stratification were recurrent themes. Conclusion: Retrieved evidence for the effectiveness of melatonin for post paediatric ABI sleep impairment appears promising. There is a clear need for further study in this area to inform clinical and research practices. Recommendations are given. |
| Keywords: | Sleep impairment paediatric melatonin acquired brain injury |