|
|||||
|
|
Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40 |
|
| Authors: | M Aziz M L M Wissing K V Naver J Faber S O Skouby |
| Institution: | 1. Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences, Herlev Hospital, Copenhagen University HerlevDenmark;2. Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences, Holbaek Hospital, Copenhagen University HolbaekDenmark;3. Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences, Hvidovre Hospital, Copenhagen UniversityDenmark;4. Department of Endocrinology, Faculty of Health and Medical Sciences, Herlev Hospital, Copenhagen University HerlevDenmark |
| Abstract: | Objective: To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP. Design: Cross-sectional study. Setting: Gynecological clinics at three Danish University Hospitals. Patients: One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria. Main outcome measures: Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR. Results: No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40. Conclusion: YKL-40, the marker of low-grade inflammation is not increased in women with PCOS. |
| Keywords: | Androgens body mass index insulin resistance low-grade inflammation PCOS |