重症急性胰腺炎113例病因及预后分析

目的 分析重症急性胰腺炎(SAP)的病因及预后,为防治急性胰腺炎提供依据.方法 回顾性分析113例SAP的病因、性别、年龄、住院天数以及预后情况.结果 113例SAP中,胆源性36例(31.88％)、酒精性48例(42.48％)、特发性10例(8.85％)、高脂血症性13例(11.50％)、混合性6例(8.31％).男∶女=2.65∶1,差异有统计学意义(x2=41.4968,P＜0.01).各类患者年龄分别为:(61.89±11.32)、(45.73±9.70)、(45.20±10.92)、(53.23±8.52)、(56.27±8.53)岁,差异有统计学意义(F=14.6,P＜0.01)；各类患者住院天数分别为:(21.11±11.50)、(19.54±16.57)、(16.00±5.19)、(21.61±8.02)、(10.83 ±9.64)d,差异无统计学意义(P＞0.05)；各组的治愈好转率及病死率之间差异均无统计学意义(均P＞0.05).结论 SAP病因大部分为胆源性及酒精性,而以酒精性为最多；胆源性SAP多为老年患者,酒精性、特发性、高脂血症性SAP患者多为中青年.尽管差异不明显,但酒精性及混合性SAP病死率较高.

Analysis of causes and prognosis of 113 patients with severe acute pancreatitis

Objective To better understand the causes and prognosis of severe acute pancreatitis （SAP）. Methods The cause,gender,age,length of hospital stay and prognosis were retrospectively analyzed in the data of 113 hospitalized patients from January 2004 to August 2010. Results The causes of 113 patients were biliary（31.88% ）, alcoholic （42.48%）, idiopathic （ 8.85 % ）, hyperlipidemie （ 11.5 % ） and mixed （ 8.31% ）. The rate of male/female was 2. 65/1 （P 〈 0.01 ）. The mean age of patients with biliary,acoholic ,idiopathic ,hyperlipidemic and mixed acute pancreatitis were 61.89 ±11.32,45.73 ± 9.70,45.20±10.92,53.23 ± 8.52,56.27 ± 8.53 years,, respectively （ P = 0. 000）. The length of hospital stay of these groups were 21.11 ± 11. 50,19.54± 16.57,16.00± 5.19,21.61 v 8.02,10.83 ± 9.64 days, respectively （ P = 0. 396 ）. There were not significant differences about cure rate and mortality among groups （P 〉 0.05 ）. Conclusion The majority causes of SAP were biliary and alcoholic, and the acohol was the most cause. Biliary SAP was highest in older patients ,whereas aeoholic ,idiopathic and hyperlipidemic SAP were highest in young patients. Although the difference was not statistically significant,the mortality of acoholic and mixed SAP were higher.