Polyovular follicles in the ovary of immature mice exposed prenatally to diethylstilbestrol |
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Authors: | Taisen Iguchi and Noboru Takasugi |
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Institution: | (1) Department of Biology, Yokohama City University, Kanazawa-Ku, Yokohama, Japan |
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Abstract: | Summary Polyovular follicles (PF) occur in the ovary of 30-day-old offspring of ICR/JCL mice given 4 daily subcutaneous injections of 20–2,000 g diethylstilbestrol (DES)/day from days 15 to 18 of gestation. PF containing 2–9 oocytes per follicle in the prenatally DES-exposed mice are increased 33- to 112-fold as compared to controls. In 5- to 25-day-old offspring of mothers given injections of 2,000 g DES/day, PF are observed 17–65 times more frequent than in controls. |
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Keywords: | Polyovular follicles Prenatal DES exposure Mouse |
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