国产氟罗沙星治疗急性细菌性感染的多中心临床研究

为在较大范围内考察国产氟罗沙星治疗急性细菌性感染的安全性和有效性，本文采用开放性无对照试验方法治疗呼吸系统、泌尿生殖系统和其它部位细菌性感染1020例。给药方法为每次口服200mg，每日2次或400mg、每日1次，疗程5－14d。结果表明，总痊愈率和总有效率分别为62．27％和92．61％，细菌清除率为91．86％，不良发生率为12．16％。不良反应多呈轻度至中度，患者多可耐受，仅5例患者因不良反应停药。

A multicentre clinical study on domestic fleroxacin in the treatment of acute bacterial infections

To evaluate the safety and efficacy of domestic fleroxacin, 1020 patients with acute bacterial infections in respiratory tract, urinary tract, digestive tract, and other infections were treated with the drug in an open trial. Fleroxacin was administered orally 200mg twice daily or 400mg once daily for 5~14 days. Results showed that the total cure rate, effective rate and the bacterial eradication rate were 62.27%, 92.61% and 91.86% respectively. Adverse events attributing to drug treatment occurred in 124 patients (12.16%). They were generally mild or moderate and well tolerated. Only 5 patients was withdrawn from the trial because of the drug adverse reactions.