| 诱导型一氧化氮合酶在心肌缺血/再灌注损伤中的研究进展 |
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| 引用本文： | 杨彦鹏.诱导型一氧化氮合酶在心肌缺血/再灌注损伤中的研究进展[J].心血管病学进展,2012,33(2):278-281. |
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| 作者姓名： | 杨彦鹏 |
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| 作者单位： | 重庆医科大学附属第一医院心血管内科,重庆,400016 |
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| 基金项目： | 重庆市自然科学基金资助项目 |
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| 摘 要： | 采用溶栓疗法、动脉搭桥术、冠状动脉血管成形术等技术,使缺血组织和器官重新恢复血流,挽救了众多危急重病人的生命,然而,缺血器官及组织在恢复血流的同时,均伴随着缺血/再灌注损伤,是目前临床上亟待解决的问题。在对心血管疾病的研究过程中,随着心肌保护研究的不断深入,如何减轻心肌缺血/再灌注损伤成为心肌保护问题的关键。越来越多的研究表明,心肌缺血/再灌注损伤与诱导型一氧化氮合酶表达过量一氧化氮紧密相关。研究表明,诱导型一氧化氮合酶既有心肌保护作用,也有促心肌损伤作用,而通过对诱导型一氧化氮合酶抑制剂的应用,有望减轻心肌损伤的进展,保护损伤心肌。
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| 关 键 词： | 心肌缺血/再灌注损伤 诱导型一氧化氮合酶 一氧化氮 一氧化氮合酶抑制剂 |
Advances of Inducible Nitric Oxide Synthase in Myocardial Ischemia Reperfusion Injury |
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| YANG Yan-peng.Advances of Inducible Nitric Oxide Synthase in Myocardial Ischemia Reperfusion Injury[J].Advances in Cardiovascular Diseases,2012,33(2):278-281. |
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| Authors: | YANG Yan-peng |
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| Institution: | 1.Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;2.Davis Heart and Lung Research Institute,Department of Molecular and Cellular Biochemistry,The Ohio State University College of Medicine,Columbus,43210,Ohio,USA) |
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| Abstract: | The emerging techniques,such as thrombolysis,artery bypass grafting and angioplasty,restore blood flow to the ischemic organs and restore lives of life-threatening patients.However,it accompanies ischemia-reperfusion injury while the ischemic organs are re-irrigated.It is essential to reduce myocardial ischemia and reperfusion injury(MI/RI) in the intervention of cardiovascular diseases.Accumulating data demonstrates that there is close relationship between MI/RI and overexpression of inducible nitric oxide synthase(iNOS).It is validated that iNOS has myocardial protection but myocardial injury either.Thus,the application of inducible nitric oxide synthase inhibitors may alleviate the MI/RI and improve myocardial protection. |
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| Keywords: | myocardial ischemia reperfusion injury inducible nitric oxide synthase nitric oxide nitric oxide synthase inhibitors |
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