| 脂联素及受体与非酒精性脂肪性肝炎 |
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| 引用本文： | 钱晓武,范竹萍,邱德凯. 脂联素及受体与非酒精性脂肪性肝炎[J]. 国际消化病杂志, 2006, 26(3): 157-160 |
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| 作者姓名： | 钱晓武 范竹萍 邱德凯 |
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| 作者单位： | 上海交通大学医学院附属仁济医院,上海市消化疾病研究所,200001;上海交通大学医学院附属仁济医院,上海市消化疾病研究所,200001;上海交通大学医学院附属仁济医院,上海市消化疾病研究所,200001 |
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| 摘 要： | 胰岛素抵抗是非酒精性脂肪性肝炎(NASH)发病机制的关键因素。细胞因子脂联素(adiponectin) 具有增加胰岛素敏感性、抗炎症和抗动脉粥样硬化的作用。而脂联素受体(AdipoR)在adiponectin激活AMPK、增加PPARα配体活性、增加葡萄糖摄取和脂肪酸氧化时发挥介导作用。因此,对adiponectin及AdipoR的进一步研究有助于对NASH的机制和治疗有更好的认识。
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| 关 键 词： | 脂联素 脂联素受体 非酒精性脂肪性肝炎 |
| 收稿时间： | 2005-06-08 |
| 修稿时间： | 2005-06-08 |
Adiponectin and AdipoR with nonalcoholic steatohepatitis |
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| QIAN Xiao-wu,FAN Zhu-ping,QIU De-kai. Adiponectin and AdipoR with nonalcoholic steatohepatitis[J]. International Journal of Digestive Disease, 2006, 26(3): 157-160 |
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| Authors: | QIAN Xiao-wu FAN Zhu-ping QIU De-kai |
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| Abstract: | Insulin resistance play a key role in the pathogenesis of NASH. Adiponectin is an important adipocytokine with insulin-sensitizing, anti-inflammatory and antiatherogenic effect. AdipoRl and AdipoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator- activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponectin. Consequently, further investigation of adiponectin and its receptors would redound to elucidate pathogenesis and therapeutics of NASH . |
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| Keywords: | Adiponectin Adiponectin receptor Nonalcoholic steatohepatitis |
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