Studies on the plasma cholesterol and triacylglycerols in chronic methemoglobinemia in rats. |
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| Authors: | A Hristova D Iluchev V Markova N Atanasov |
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| Affiliation: | University of Medicine, Department of Pathophysiology, Plovdiv, Bulgaria. |
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| Abstract: | Plasma cholesterol and triacylglycerols were measured in rats with modelled chronic two-stage (mild and moderate) intermittent nitrite methemoglobinemia for 15 and 30 days. It was found that at the moment of methemoglobinemic peak (60 +/- 10 min) the experimental animals had mixed (hemtoxic, anemic and hypoxic) hypoxemia. The every day "pulse" decrease of the total oxygen concentration during the 30-day methemoglobinemia was accompanied with a significant rise (p < 0.05) of cholesterol concentrations in the high-density lipoproteins and the total cholesterol, as well as a decrease in the amount of triacylglycerols. These changes are considered to represent the side effects of adaptation for whose elucidation further research is needed. |
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