Genetic analysis of small ruminant lentiviruses following lactogenic transmission |
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Authors: | Giuliano Pisoni Giuseppe Bertoni Giovanni Manarolla Licia Scaccabarozzi Paolo Moroni |
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Institution: | a Università degli Studi di Milano, Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, via Celoria 10, 20133 Milano, Italyb Institute of Veterinary Virology, University of Bern, CH-3012 Bern, Switzerland |
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Abstract: | Lactogenic transmission plays an important role in the biology of lentiviruses such as HIV and SIV or the small ruminant lentiviruses (SRLV). In this work we analyzed the characteristics of viruses that goats, naturally infected with two strains of SRLV, transmitted to their kids. The spectrum of viral genotypes transmitted was broader and the efficiency of transmission greater compared to their human and simian counterparts. The newly described A10 subgroup of SRLV was more efficiently transmitted than the B1 genotype. The analysis of a particular stretch of the envelope glycoprotein encompassing a potential neutralizing epitope revealed that, as in SIV, the transmitted viruses were positively charged in this region, but, in contrast to SIV, they tended to lack a glycosylation site that might protect against antibody neutralization. We conclude that the physiology of the ruminant neonatal intestine, which permits the adsorption of infected maternal cells, shaped the evolution of these particular lentiviruses that represent a valid model of lactogenic lentivirus transmission. |
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Keywords: | Goat Small ruminant lentivirus Colostrum Milk Transmission Lactogenic transmission Genotype Lentivirus Caprine arthritis encephalitis virus Maedi-Visna virus |
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