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Computational analysis of human adenovirus serotype 18 |
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| Authors: | Michael P. Walsh Morris S. Jones |
| Affiliation: | a Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd., MSN 5B3, Manassas, VA 20110, USA b Clinical Investigation Facility, David Grant USAF Medical Center, Travis, CA 94535, USA c Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA d Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA, USA |
| Abstract: | The genome of the sole remaining unsequenced member of species A, human adenovirus type 18 (HAdV-A18), has been sequenced and analyzed. Members of species A are implicated as gastrointestinal pathogens and were shown to be tumorigenic in rodents. These whole genome and in silico proteome data are important as references for reexamining and integrating earlier work and observations based on lower resolution techniques, such as restriction enzyme digestion patterns, particularly for hypotheses based on pre-genomics data. Additionally, the genome of HAdV-A18 will also serve as reference for current studies examining the molecular evolution and origins of human and simian adenoviruses, particularly genome recombination studies. Applications of this virus as a potential vector for gene delivery protocols may be practical as data accumulate on this and other adenovirus genomes. |
| Keywords: | Human adenovirus Molecular evolution Species A Oncogenesis |
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