Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors |
| |
| Authors: | Weber F Fukino K Sawada T Williams N Sweet K Brena R M Plass C Caldes T Mutter G L Villalona-Calero M A Eng C |
| |
| Affiliation: | Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. |
| |
| Abstract: | Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy. |
| |
| Keywords: | small-molecule therapy tyrosine kinase EGFR mutation breast cancer |
| 本文献已被 PubMed 等数据库收录！ |
