稳定性同位素评价藏族青年男子膳食铁的吸收率

目的用铁的稳定性同位素示踪剂评价藏族青年男子膳食铁的吸收率,为改善该人群膳食铁吸收的提供参考数据。方法于现场进行人体代谢试验,受试者口服稳定性同位素示踪铁剂(浓集57Fe的FeSO4)及稀土元素镝,粪便监测法收集示踪剂排出粪样;用感耦等离子体质谱仪测定粪样57Fe56Fe的比值,分析评价该人群膳食铁的吸收率。结果口服同位素评价藏族青年男子膳食铁的吸收率为13.4%±6.4%;每日示踪剂铁和镝排出呈良好相关性。结论稀土元素镝与未吸收的示踪剂铁在消化道有一致的排出过程,前者的回收率能很好反映粪样收集情况;藏族成年男子膳食铁的吸收较好。

Evaluation on the dietary iron absorption by young Tibetan men using stable isotopic tracer

OBJECTIVE: The study was aimed to evaluate the iron absorption in the Tibetan man's diet using the stable isotopic iron, and present a reference to improve the dietary iron absorption for Chinese. METHODS: In the study conducted on the spot of high altitude (> 3500m), the iron tracer (FeSO4 enriched with 57Fe) and the recovery indicator dysprosium (Dy) were orally administrated to 16 young Tibetan men, and their feces were sampled. The ratios of 57Fe/56Fe in fecal samples was determined by inductively coupled plasma mass spectrometry, and then the iron absorption was calculated based on the principle of isotope dilution. RESULTS: The rate of dietary iron absorption in young Tibetan men was 13.4% +/- 6.4% with good linear correlation between daily fecal excretions of iron tracer and Dy. CONCLUSION: Dy had the same behavior as non-absorbed iron tracer in the digestive tract and the recovery of Dy may indicate the completeness of fecal collection. Dietary iron absorption in the adult Tibetan man was relatively high.