| 小儿静脉穿刺消毒液的制备及质量控制 |
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| 引用本文： | 惠培业,刘梅和,魏文华,赵红,付爱芬,刘峰. 小儿静脉穿刺消毒液的制备及质量控制[J]. 中国药房, 2005, 16(23): 1790-1791 |
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| 作者姓名： | 惠培业 刘梅和 魏文华 赵红 付爱芬 刘峰 |
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| 作者单位： | 山东潍坊市妇幼保健院,潍坊市,261011 |
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| 摘 要： | 目的:制备小儿静脉穿刺消毒液并建立其质量控制方法。方法:以消旋山莨菪碱、烟酸为主药,以75%乙醇为溶剂,配制小儿静脉穿刺消毒液;采用非水滴定法、紫外分光光度法分别测定消旋山莨菪碱、烟酸的含量。结果:消旋山莨菪碱、烟酸平均回收率分别为99·96%(RSD=0·04%)、100·04%(RSD=0·16%),标示量均在98·87%~100·8%内。结论:本方法快速、简便、分辨率高、结果准确,适用于该制剂的质量控制。
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| 关 键 词： | 消旋山莨菪碱 烟酸 月桂氮酮 制备 质量控制 |
| 文章编号： | 1001-0408（2005）23-1790-02 |
| 收稿时间： | 2005-06-17 |
| 修稿时间： | 2005-09-08 |
Preparation and Quality Control of Disinfectant for Venepuncture in Children |
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| HUI Peiye,LIU Meihe,WEI Wenhua,ZHAO Hong,FU Aifen,LIU Feng. Preparation and Quality Control of Disinfectant for Venepuncture in Children[J]. China Pharmacy, 2005, 16(23): 1790-1791 |
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| Authors: | HUI Peiye LIU Meihe WEI Wenhua ZHAO Hong FU Aifen LIU Feng |
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| Affiliation: | Weifang Maternal and Child Health Hospital of Shandong Province, Weifang 261011,China |
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| Abstract: | OBJECTIVE: To prepare the disinfectant for venepuncture in children and to establish the quality control for this preparation. METHODS: Nicotinic acid and racanisodamine were taken as the chief components for the preparation of this disinfectant, 75% alcohol as the solvent. Nicotinic acid were determined by ultraviolet and visible spectrophotometry(UV-Vis); racanisodamine were determined by nonaqueous titrations. RESULTS: The average recoveries of racanisodamine and nicotinic acid were 99.96%(RSD=0.04%) and 100.04%(RSD=0.16%) respectively, which all were in the range of 98.87%～100.8%. CONCLUSION: The disinfectant produced with the established method is simple in preparation, accurate in content determination, stable and reliable in quality. |
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| Keywords: | Racanisodamine Nicotinic acid Laurocapram Preparation Quality control |
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