| 南海海绵Rhabdastrella aff. Distincta中活性成分分离与鉴定 |
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| 引用本文： | 吕芳,林文翰.南海海绵Rhabdastrella aff. Distincta中活性成分分离与鉴定[J].中国中药杂志,2006,31(11):894-898. |
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| 作者姓名： | 吕芳 林文翰 |
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| 作者单位： | 北京大学,天然药物与仿生药物国家重点实验室,北京,100083 |
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| 摘 要： | 目的:对南海海绵Rhabdastrella aff.distincta进行活性成分的研究。方法:利用正相硅胶柱色谱、Sephadex LH-20柱色谱、ODS及甲酯化等方法分离纯化,1D和2D NMR及MS方法进行结构鉴定,并通过MTT法和SRB法测试生物活性。结果:从氯仿萃取部分分离鉴定8个化合物,分别为geoditin A(1),B(2),stellettin A(5),B(4),C(3),E(7),rhabdastrellic acid A(8),以及stellettin E甲酯化产物(6)。结论:所有化合物均首次从该海绵中分离鉴定,并且对多数所选的肿瘤细胞株显示一定的细胞毒性。
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| 关 键 词： | 海绵 异臭椿类三萜 生物活性 |
| 文章编号： | 1001-5302（2006）11-0894-05 |
| 收稿时间： | 2006-02-25 |
| 修稿时间： | 2006-02-25 |
Bioactive isomalabaricane triterpenes isolated from marine sponge Rhabdastrella aff. Distincta |
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| LU Fang;LIN Wen-han.Bioactive isomalabaricane triterpenes isolated from marine sponge Rhabdastrella aff. Distincta[J].China Journal of Chinese Materia Medica,2006,31(11):894-898. |
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| Authors: | LU Fang;LIN Wen-han |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, Peking University,Beijing 100083, China |
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| Abstract: | Objective: To study the chemical constituents of the marine sponge Rhabdastrella aff.distincta/.Method: Compounds were obtained by normal phase silica gel,Sephadex LH-20,reverse phase chromatogrophy and methylation method.These structures were determined on the basis of IR,MS,NMR spectral analysis.Result: Eight compounds were isolated from bioactive CH3Cl fraction and identified as geoditin A(1),geoditin B(2),stellettin A(5),stellettin B(4),stellettin C (3),stellettinE(7),rhabdastrellic acid A(8) and the methyl ester of stellettin E(6).Conclusion: All these compounds were obtained from this species for the first time. |
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| Keywords: | Rhabdastrella aff distincta marine sponge isomalabaricane triterpenes bioactivity |
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