| 外周伤害性刺激及吗啡对大鼠丘脑束旁核痛抑制-兴奋神经元电活动的影响 |
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| 引用本文： | 李柏岩,马和平,徐屯.外周伤害性刺激及吗啡对大鼠丘脑束旁核痛抑制-兴奋神经元电活动的影响[J].哈尔滨医科大学学报,1988(6). |
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| 作者姓名： | 李柏岩 马和平 徐屯 |
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| 作者单位： | 哈尔滨医科大学生理学教研室
(李柏岩，马和平)，哈尔滨医科大学生理学教研室(徐屯) |
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| 摘 要： | 应用细胞外微电极技术,观察和记录了Pf痛反应神经元对伤害性夹尾、伤害性电刺激坐骨神经和检验性刺激及脑内微量注射吗啡前后电活动变化的情况。在67只Wistar大鼠右侧Pf内记录了309个痛反应神经元,其中PI-EN64个,占神经元总数的20.71%。PI-EN对伤害性夹尾和电刺激坐骨神经均发生特异性的抑制-兴奋反应,对非伤害性刺激则不发生反应。伤害性刺激诱发放电之前有
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| 关 键 词： | 束旁核(Pf) 痛抑制-兴奋神经元(PI-EN) 吗啡 纳洛酮 |
Influence of Different Kinds of Noxious Stimulation and Morphine on the Electric Activities of Pain Inhibition-excitation Neuron in Nucleus Parafascicularis of Rat |
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| Li Baiyan et al.Influence of Different Kinds of Noxious Stimulation and Morphine on the Electric Activities of Pain Inhibition-excitation Neuron in Nucleus Parafascicularis of Rat[J].Journal of Harbin Medical University,1988(6). |
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| Authors: | Li Baiyan |
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| Institution: | Department of physiology |
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| Abstract: | In this experiment, the techniques of microelectrode outside cell and intracerebral microinjection are used to record the single unit discharges of neurons and observe the influence of analgesic on the evoked discharges of neurons. The responses of 309 neurons in parafascicularis(Pf) to noxious stimulation and testing stimulation were recorded. Three patterns of the responses were distinguished according to the quality of responses and showed the characteristic of nocicepation. Among 309 Pf units, 64 were pain inhibitionexcitation neuron(PI-EN). The results indicated that (1)PI-EN exist indeed in Pf and differ from pain-excitation neuron (PEN) and pain-inhibition neuron(PIN); (2)PI-EN has the characteristics of normal pain-reaction neurons; (3)morphine can inhibite the responses of PI-EN to noxious stimulation and the effects can be blocked and reversed by the naloxone. |
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| Keywords: | Parafascicularis Pain inhibition-excitation neuron Morphine Naloxone |
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