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Brain endothelial cell expression of SPARCL‐1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro
Authors:C. Bridel  M. J. A. Koel‐Simmelink  L. Peferoen  C. Derada Troletti  S. Durieux  R. Gorter  E. Nutma  P. Gami  E. Iacobaeus  L. Brundin  J. Kuhle  H. Vrenken  J. Killestein  S. R. Piersma  T. V. Pham  H. E. De Vries  S. Amor  C. R. Jimenez  C. E. Teunissen
Affiliation:1. Department of Clinical Chemistry, Neurochemistry Lab and Biobank, VU Medical Centre, Amsterdam, The Netherlands;2. Department of Pathology, VU Medical Centre, Amsterdam, The Netherlands;3. Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands;4. Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institute, Solna, Sweden;5. Center for Molecular Medicine, Stockholm, Sweden;6. Neurology, Department of Medicine, Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland;7. Department of Radiology and Nuclear Medicine and Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands;8. Department of Neurology, MS Centre Amsterdam, VU Medical Centre, Amsterdam, The Netherlands;9. Department of Medical Oncology, OncoProteomics Laboratory, VU Medical Centre, Amsterdam, The Netherlands;10. Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK
Abstract:
Keywords:biomarker  blood brain barrier  cerebrospinal fluid  chronic lesions  Multiple sclerosis  SPARCL‐1
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