Advances in Frontline Management of Peripheral T-cell Lymphoma |
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| Authors: | Chathuri Abeyakoon Carrie van der Weyden Sean Harrop Amit Khot Michael Dickinson Costas K. Yannakou H. Miles Prince |
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| Affiliation: | 1. Department of Haematology, Epworth HealthCare, Melbourne, Victoria, Australia;2. Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;3. Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia;4. Department of Haematology, Royal Melbourne Hospital, Melbourne, Victoria, Australia;1. Department of Radiation Oncology Duke University Medical Center, Durham, NC;2. Department of Pathology, Duke University Medical Center, Durham, NC;3. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC;4. Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC;1. Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China;2. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China;1. Department of Hematology/Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Department of Hematology/Oncology, Children''s Hospital of Soochow University, Suzhou, Jiangsu Province, China;1. Department of Medicine (Hematology) and The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada;2. Department of Medicine, Queen’s University, Kingston, ON, Canada;1. Hans Messner Allogeneic Transplant Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada;2. Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada;1. Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece;2. Plasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece |
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| Abstract: | Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphomas that are frequently associated with a poor prognosis. For many decades, the standard-of-care has been CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone)-based therapy, but it is well-recognized that survival outcomes are unsatisfactory, especially when compared with B-cell lymphomas. Major recent advances in cancer diagnosis and management have the potential to significantly improve PTCL outcomes. These include: (1) improved diagnostic techniques that incorporate molecular genetic data to further refine diagnosis and subtyping; (2) the development of novel agents; and (3) improved monitoring modalities, such as 18F-fluorodeoxyglucose positron emission tomography-computed tomography scans and circulating tumor DNA. In this review, we aim to explore these 3 advances in the context of frontline management of PTCL. |
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| Keywords: | Disease monitoring Hematopoietic stem cell transplantation Molecular diagnostics Novel agents Radiotherapy |
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