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Antithrombotic strategies in elderly patients with acute coronary syndrome

Authors:	Jean-Guillaume Dillinger Marc Laine Sara Bouajila Franck Paganelli Patrick Henry Laurent Bonello

Affiliation:	1. Department of cardiology, Hôpital Lariboisière, AP–HP, Inserm U-942, Université de Paris, 2, rue Ambroise-Paré, 75010 Paris, France;2. Mediterranean Association for research and studies in cardiology (MARS cardio), Centre for cardiovascular and nutrition research, AP–HM, Aix-Marseille University, INSERM 1263, INRA 1260, 13015 Marseille, France;3. Cardiology department, Hôpital Nord, 13015 Marseille, France;4. Mediterranean Association for research and studies in cardiology (MARS cardio), 13015 Marseille, France

Abstract:	Central illustration. Anti-thrombotic strategies in patients with acute coronary syndrome. ACS: acute coronary syndrome; ADP: adenosine diphosphate; CAD: coronary artery disease; CRP: C-reactive protein; IL-6; interleukin-6; DAPT: dual antiplatelet therapy; GRACE: Global Registry of Acute Coronary Events; NSTEMI: non-ST-segment elevation myocardial infarction; PAI-1: plasminogen activator inhibitor-1; PCI: percutaneous coronary intervention; PG12: prostaglandin 12; PPI: proton pump inhibitor; PRECISE-DAPT: PREdicting bleeding Complications in patients undergoing stent Implantation and SubsequEnt Dual AntiPlatelet Therapy; REACH: REduction of Atherothrombosis for Continued Health; STEMI: ST-segment elevation myocardial infarction; TIMI: Thrombolysis In Myocardial Infarction; Vwf: von Willebrand factor.
Keywords:	Elderly Acute coronary syndrome Antiplatelet Ischaemic Bleeding Sujet âgé Syndrome coronaire aigu Antiagrégant plaquettaire Ischémie Saignement ACS" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" acute coronary syndrome BARC" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" Bleeding Academic Research Consortium CI" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" confidence interval DAPT" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" dual antiplatelet therapy GPI" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" glycoprotein IIb/IIIa inhibitor HR" },{" #name" :" keyword" ," $" :{" id" :" kw0110" }," $$" :[{" #name" :" text" ," _" :" hazard ratio MACE" },{" #name" :" keyword" ," $" :{" id" :" kw0120" }," $$" :[{" #name" :" text" ," _" :" major adverse cardiovascular events NOAC" },{" #name" :" keyword" ," $" :{" id" :" kw0130" }," $$" :[{" #name" :" text" ," _" :" non-vitamin K antagonist oral anticoagulant NSTEMI" },{" #name" :" keyword" ," $" :{" id" :" kw0140" }," $$" :[{" #name" :" text" ," _" :" non?ST-segment elevation myocardial infarction PCI" },{" #name" :" keyword" ," $" :{" id" :" kw0150" }," $$" :[{" #name" :" text" ," _" :" percutaneous coronary intervention STEMI" },{" #name" :" keyword" ," $" :{" id" :" kw0160" }," $$" :[{" #name" :" text" ," _" :" ST-segment elevation myocardial infarction TIMI" },{" #name" :" keyword" ," $" :{" id" :" kw0170" }," $$" :[{" #name" :" text" ," _" :" thrombolysis in myocardial infarction UFH" },{" #name" :" keyword" ," $" :{" id" :" kw0180" }," $$" :[{" #name" :" text" ," _" :" unfractionated heparin VKA" },{" #name" :" keyword" ," $" :{" id" :" kw0190" }," $$" :[{" #name" :" text" ," _" :" vitamin K antagonist
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