| 附睾特异性基因的表达与调控 |
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| 引用本文： | 曹少锋,徐晨. 附睾特异性基因的表达与调控[J]. 中华男科学杂志, 2006, 12(1): 71-74 |
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| 作者姓名： | 曹少锋 徐晨 |
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| 作者单位： | 上海交通大学医学院组织胚胎学教研室,上海市生殖医学重点实验室,上海,200025 |
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| 摘 要： | 哺乳动物的附睾是一条高度卷曲的管道系统,附睾上皮是执行附睾功能的重要组成部分。附睾上皮蛋白质的合成与分泌,为精子提供了一个特殊的、不断改变的管腔液体环境,使其在附睾内运行过程中获得运动能力并最终达到功能成熟。附睾特异性表达的基因具有高度区域化的特征,受雄激素和(或)睾丸因子的调控,在出生后发育中呈现时空特异性的表达模式,这些都提示它们在附睾中发挥着重要而独特的作用。
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| 关 键 词： | 附睾 基因表达 调控 |
| 文章编号： | 1009-3591（2006）01-0071-04 |
| 收稿时间： | 2005-02-08 |
| 修稿时间： | 2005-07-14 |
Specialized Gene Expression and Regulation in the Epididymis |
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| CAO Shao-feng,XU Chen. Specialized Gene Expression and Regulation in the Epididymis[J]. National journal of andrology, 2006, 12(1): 71-74 |
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| Authors: | CAO Shao-feng XU Chen |
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| Affiliation: | Department of Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanhai Key Laboratory for Reproductive Medicine, Shanghai 200025, China |
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| Abstract: | The epididymis is a single and highly convoluted tubule system in mammals.The epithelium is the major compartment for epididymal function.Proteins synthesized and secreted by epididymal epithelium provide a special and ever-changing luminal fluid environment for sperm as they progress through the epididymis,which makes sperm achieve motility and ultimately results in sperm functional maturation.Specialized genes expressed in the epididymis have regional-specific characteristics.They are regulated by androgen and /or testicular factors and present spatial and tempal-specialized expression pattern in postnatal development,all these hint that they play important and unique roles in epididymis. |
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| Keywords: | epididymis gene expression regulation |
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