DNA定量分析联合阴道镜在宫颈癌诊断中的价值

目的:探讨宫颈细胞DNA定量分析法联合阴道镜检查在宫颈癌诊断中的价值。方法:对400例妇女的宫颈细胞采用DNA定量分析系统进行检查,DNA定量分析异常者在阴道镜下行宫颈活组织病理检查。结果:400例妇女做了病理活检,病理诊断宫颈癌及宫颈上皮内瘤变(CIN)2以上病变共43例,其中DNA定量分析方法异常40例(93.0%),阴道镜异常35例(81.4%),二者间差异有统计学意义(P<0.05)。DNA定量分析及阴道镜检查筛查子宫颈癌及高级别宫颈上皮内瘤变(≥CIN2)的敏感度高于单纯DNA定量分析,假阴性率低于单纯DNA定量分析。结论:DNA定量分析方法联合阴道镜在早期诊断宫颈癌及高级别宫颈上皮内瘤变方面有更高的敏感性,适合在基层单位大力推广。

Value of DNA quantitative analysis combining with colposcopy for diagnosis of cervical cancer

Objective: To explore the value of DNA quantitative analysis of cervical cells combining with colposcopy for diagnosis of cervical cancer.Methods: The cervical cells of 400 women were examined by DNA quantitative analysis system,and the women with abnormal results of DNA quantitative analysis underwent cervical biopsy under colposcope and pathological examination.Results:All women underwent pathological biopsy,and 43 women were diagnosed as cervical cancer and ≥CIN Ⅱ lesions,40 women(93.0%) were found with abnormal results of DNA quantitative analysis,35 women(81.4%) were found with abnormal results of colposcopy,there was statistically significant difference between the two results(P<0.05).The sensitivities of DNA quantitative analysis and colposcopy for screening of cervical cancer and ≥CIN Ⅱ lesions were superior to DNA quantitative analysis alone,but false negative rates were lower.Conclusion: DNA quantitative analysis combined with colposcopy has higher sensitivity for early diagnosis of cervical cancer and high-grade CIN,which is suitable for popularization in primary medical institutions.