| MMP-2基因启动子区多态性与子宫内膜异位症易感性研究 |
| |
| 引用本文： | 周明,郭蓉,曾秀华,王春平,罗忆,黄晓玲.MMP-2基因启动子区多态性与子宫内膜异位症易感性研究[J].海南医学院学报,2013,19(1):15-17. |
| |
| 作者姓名： | 周明 郭蓉 曾秀华 王春平 罗忆 黄晓玲 |
| |
| 作者单位： | 深圳市第五人民医院妇产科,广东深圳,518001 |
| |
| 基金项目： | 深圳市科技计划项目(项目编号:201202188);Financially Supported by Special Foundation for Clinical Studies from Committee of Medical Journal of Chinese Universities(11221022) |
| |
| 摘 要： | 目的:探讨MMP-2启动子区基因多态性与广东地区妇女子宫内膜异位症(EMs)易感性的关系。方法:采用聚合酶链反应-限制性片段长度多态方法(PCT-RFLP)对77例EMs及83例对照组MMP-2启动子区基因多态位点的基因型分析。结果:MMP-2基因的基因型(P=0.97)以及等位基因频率(P=0.82)的分布差异均无统计学意义。结论:MMP-2启动子区-735C/T基因多态性与广东地区妇女子宫内膜异位症(EMs)易感性无明显相关性。
|
| 关 键 词： | 子宫内膜异位症 MMP-2 基因多态性 |
Correlation between promoter polymorphism of MMP-2 and susceptibility of endometriosis |
| |
| ZHOU Ming,GUO Rong,ZENG Xiu-hua,WANG Chun-ping,LUO Yi,HUANG Xiao-ling.Correlation between promoter polymorphism of MMP-2 and susceptibility of endometriosis[J].Journal of Hainan Medical College,2013,19(1):15-17. |
| |
| Authors: | ZHOU Ming GUO Rong ZENG Xiu-hua WANG Chun-ping LUO Yi HUANG Xiao-ling |
| |
| Institution: | (Fifth People’s Hospital of Shenzhen,Shenzhen 518001,China) |
| |
| Abstract: | Objective: To explore the relationship between MMP-2 promoter region gene polymorphism and susceptibility of women endometriosis(EMs) in Guangdong Province.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCT-RFLP) method was applied to analyze MMP-2 promoter region gene polymorphism in 77 cases of EMs and 83 cases of control group.Results: MMP-2 gene genotype(P=0.97) and allele frequency(P=0.82) distribution differences were not statistical significant.Conclusion:There was no significant correlation between MMP-2 promoter region 735 C/T gene polymorphism and the susceptibility of women endometriosis(EMs) in Guangdong. |
| |
| Keywords: | Endometriosis MMP-2 Polymorphism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
