酒精性肝硬化和肝炎后肝硬化的临床特点分析

目的：探讨酒精性肝硬化与肝炎后肝硬化的临床特点。方法：对46例酒精性肝硬化患者与同期住院的肝炎后肝硬化患者为对照进行回顾性分析。结果：酒精性肝硬化辅助检查示谷氨酰基转移酶（GGT）升高，天冬氨酸氨基转移酶（AST）／血清丙氨酸基转移酶（ALT）、血尿酸（uA）等升高明显，肝大、脂肪肝、胆囊炎、胆石症、胰腺炎发生比例较肝炎后肝硬化高，与肝炎后肝硬化比较差异显著（P〈0．05）。结论：酒精性肝硬化患者的血清GGT升高显著。提示GGT是反映酒精性肝硬化的特征性指标。酒精性肝硬化预后比肝炎后肝硬化好，但晚期二者预后差别不大。因此，早发现、早诊断、早治疗可明显改善酒精性肝硬化患者的预后。

Analysis of Clinical Features of Alcoholic Cirrhosis and Posthepatitic Cirrhosis

Objective： To discuss the clinical features of alcoholic cirrhosis and posthepatitic cirrhosis. Method ： Retrospective analysis was carried out by comparing 46 cases of alcoholic cirrhosis with posthepatit- ic cirrhosis patients hospitalized in the same period. Result： It was shown by auxiliary examination for alco- holic cirrhosis that glutamyltransferase （GGT） level increased, while aspartate aminotransferase {AST）/al- anine aminotransferase （ALT） and blood uric acid （ UA ） levels elevated remarkably. The incidence of hep- atomegaly, adiposis hepatica, cholecystitis, cholelithiasis and pancreatitis in alcoholic cirrhosis group was higher than that in posthepatitic cirrhosis group. The difference was statistical significance （ P〈0.05 }. Con- clusion： The GGT in alcoholic cirrhosis patients increased remarkably, which indicating GGT is a character- istics index for alcoholic cirrhosis. Though alcoholic cirrhosis has better prognosis than posthepatitic cirrho- sis, there is no clear difference between them in advanced stage. Thus, early detection, early diagnosis and early treatment can improve the prognosis of alcoholic cirrhosis significantly.