| EB病毒与上呼吸道NK/T细胞淋巴瘤的关系 |
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| 引用本文： | 陶晶,卢永田,王晓彬.EB病毒与上呼吸道NK/T细胞淋巴瘤的关系[J].海南医学院学报,2013,19(1):21-24. |
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| 作者姓名： | 陶晶 卢永田 王晓彬 |
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| 作者单位： | 深圳市第二人民医院耳鼻咽喉头颈外科,广东深圳,518000 |
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| 基金项目： | 中国高校医学期刊临床专项资金项目(112210468)~~ |
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| 摘 要： | 目的:研究上呼吸道NK/T细胞淋巴瘤的病理及免疫表型特征,探讨EB病毒(EBV)感染和上呼吸道NK/T细胞淋巴瘤发生、发展的关系。方法:采用免疫组织化学方法检测47例上呼吸道NK/T细胞淋巴瘤中有关免疫表型CD20、CD3、CD79a、细胞毒颗粒相关抗原-1(TIA-1)、CD56、CD45RO、颗粒酶B(Granzyme B),以此确定上呼吸道NK/T细胞淋巴瘤细胞免疫表型及EBV潜伏蛋白(LMP-1),原位杂交技术检测EBV编码的RNA(EBER 1/2)。结果:CD3、CD56、CD45RO、Granzyme B阳性表达率达100.0%,EBER阳性表达率达87.2%;LMP-1阳性表达率为40.4%。结论:感染EBV与上呼吸道NK/T细胞淋巴瘤的发生、发展有密切关系。
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| 关 键 词： | 上呼吸道 NK/T淋巴瘤 EB病毒 免疫组化 原位杂交 |
Association between upper respiratory tract NK/T lymphomas and Epstein-Barr virus |
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| TAO Jing,LU Yong-tian,WANG Xiao-bin.Association between upper respiratory tract NK/T lymphomas and Epstein-Barr virus[J].Journal of Hainan Medical College,2013,19(1):21-24. |
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| Authors: | TAO Jing LU Yong-tian WANG Xiao-bin |
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| Institution: | TAO Jing,LU Yong-tian,WANG Xiao-bin |
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| Abstract: | Objective: To study the immunophenotypic features of the upper respiratory tract NK/T cell lymphoma and its association with Epstin-Barr virus(EBV) infection.Methods: LCA、CD20、CD3、CD79a、CD56、CD45RO、TIA-1、Granzyme B in 47 cases of NK/T cell lymphoma were detected by immunohistochemistry staining method.The expression of EBV-latent membrane protein(LMP-1) were detected by immunohistochemistry,EBV-encoded RNA(EBER 1/2) were detected by in situ hybridization.Results: Among these cases,LCA、CD3、CD56、CD45RO、TIA-1、Granzyme B were positive in the 47 cases(100%).The positive rates of EBER 1/2 and LMP-1 were 82.3% and 40.4%.Conclusion: The occurrence and progression of NK/T cell lymphoma is closely associated with EBV infection. |
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| Keywords: | Upper respiratory NK/T lymphoma Epstin-Barr virus immunohistochemistry In situ hybridization |
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