| 小鼠白细胞减少模型白细胞及骨髓粒系细胞的动态变化 |
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| 引用本文： | 王和平,赵喜新,田开宇.小鼠白细胞减少模型白细胞及骨髓粒系细胞的动态变化[J].郑州大学学报(医学版),2002,37(4):439-440. |
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| 作者姓名： | 王和平 赵喜新 田开宇 |
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| 作者单位： | 1. 河南省医学科学研究所,郑州,450052
2. 河南中医学院针推系,郑州,450008 |
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| 基金项目： | 河南省自然科学基金资助项目 0 0 40 2 5 40 0，江苏省针灸学重点实验室开放课题 k2 0 94 |
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| 摘 要： | 目的:建立白细胞减少小鼠模型，了解白细胞及骨髓粒系的动态变化。方法：用环磷酰胺（CY）200mg/kg剂量一次性小鼠腹腔注射，注射后第3d、5d、7d，检测外周血白细胞总数、白细胞分类计数、中性粒细胞核象、骨髓细胞分类计数。结果与结论：此模型在CY毒性过后从造血干细胞开始分裂增殖，发育成杆状核中性粒细胞约需96h，成熟澉中最幼稚的中性粒细胞发育到衰亡亦需96h。推测此模型小鼠白细胞回复后还会一个红细胞减少的时相。
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| 关 键 词： | 环磷酰胺 小鼠 白细胞 骨髓 |
| 修稿时间： | 2002年2月25日 |
Dynamic changes of leukocyte and myelogram in the rat leukopenia model |
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| WANG Heping ,ZHAO Xixin ,TIAN Kaiyu Henan Provincial Research Institute of Medical Sciences Zhengzhou Henan College of Traditional Chinese Medicine,Zhengzhou.Dynamic changes of leukocyte and myelogram in the rat leukopenia model[J].Journal of Zhengzhou University: Med Sci,2002,37(4):439-440. |
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| Authors: | WANG Heping ZHAO Xixin TIAN Kaiyu Henan Provincial Research Institute of Medical Sciences Zhengzhou Henan College of Traditional Chinese Medicine Zhengzhou |
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| Institution: | WANG Heping 1),ZHAO Xixin 2),TIAN Kaiyu 2) 1)Henan Provincial Research Institute of Medical Sciences Zhengzhou 450052 2) Henan College of Traditional Chinese Medicine,Zhengzhou 450008 |
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| Abstract: | Aim:To establish a leukopenia model of rat and observe the dynamic changes of WBC and myelogram. Methods: Cyclophosphamide (CY) (200 mg/kg) was injected into rats' abdominal cavity .On the 3rd,5th and 7th day after injection, peripheral WBC,differential WBC and myelogram were detected, and the dynamic process of descent and rebound of WBC were analyzed. Results and Conclusion: After CY's toxic period of the rat model it takes 96 hours for hemopoietic stem cell to split,proliferate and develop into stab neutrophil leukocyte, besides, it also takes 96 hours for juvenile neutrophil leukocyte in the maturation pool to develop till senility.Therefore,it suggests that in the rat leukopenia model after WBC rebound there should be a phase of RBC descent. |
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| Keywords: | cyclophosphamide rat WBC marrow |
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