盐酸山莨菪碱对噪声暴露后耳蜗琥珀酸脱氢酶活性的影响

目的：观测豚鼠在噪声暴露后不同时间内盐酸山莨菪碱（６５４－２０防治组和损伤组的耳蜗琥珀酸脱氢酶（ＳＤＨ）活性变化，探讨噪声暴露后ＳＤＨ活性的变化趋势以及６５４－２在噪声暴露中对ＳＤＨ活性的影响。方法：把豚鼠分成对照组、损伤组与６５４－２防治组，在噪声暴露后不同时期，用Ｎａｃｈｌａｓ四唑氮盐法及图象分析仪显示并测算ＳＤＨ活性。结果：在噪声暴露后第３天，各组酶活性损伤最重。各组耳蜗ＳＤＨ活性第１、２回

Effect of Anisodamine on the Activity of Succinate Dehydrogenase after Noise Exposure

Objective: By observing the changes of succinate dehydrogenase (SDH) activity and ABR in cochlear of guinea-pigs between 654-2 prevention treatment group and the damaged group in different times following after noise exposed. We explicated the changing trend of SDH activity and the effect of 654-2 on the activity of SDH after noise exposed. Methods: Guinea-pigs were divided into three groups: the control group, the damaged group, and the prevention-treatment group (654-2 group). Nachlas's method and image pattern analysismeter were applied to observe the activity of SDH in different times after noise exposed. Results: Activity of SDH of each group was damaged most seriously on the third day after noise exposure. The activity of SDH of each group shows that 1st and the 2nd gyre were damaged more seriously than that of the 3rd and the 4th gyre in cochlea. The activity of SDH of 654-2 group was damaged slighter than that of the damage group. Conclusion: The results showed that white noise had a distinct affect on high frequency hearing threshold. 654-2 can prevent and treat noise-induced hearing damage in certain degree.