高能饲料诱导大鼠肥胖及对其脂质代谢的影响

目的　探讨高能饲料诱导大鼠肥胖及对大鼠脂代谢的影响。方法　实验大鼠分为 2组 ,分别给予基础饲料和高能饲料 ,喂养 7周 ,检测大鼠血脂、瘦素 (leptin)、血清超氧化物歧化酶 (superoxidedismutase ,SOD)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶 (glutathioneperoxidase,GSH Px)及体重、体脂含量等。 结果　高能饲料诱导大鼠肥胖、肥胖大鼠血清甘油三酯 (triglyceride)、胆固醇 (cholesterol)、瘦素水平升高 (分别为P <0 0 5和P <0 0 1) ,SOD活性降低 (P <0 0 5 ) ,GSH -Px活性增强 (P <0 0 5 ) ,MDA水平升高 ,但与基础饲料组相比无显著性差异(P >0 0 5 )。结论　高能饲料诱导大鼠肥胖 ,引起瘦素抵抗 ,脂质代谢紊乱 ,机体抗氧化能力降低

Obesity induced by high energy diet and its effects on lipid metabolism of rat

Objective To study obesity induced by high energy diet and its effects on lipid metabolism of rat.Methods The rats were divided into two groups,one fed with basic diet and the other with high energy diet.At the end of the 7th week,different indexes were tested such as body weight,body fat content,blood lipid,leptin,SOD,MDA and GSH-Px.Results High energy diet induced obesity.Compared with basic diet group,the levels of triglyceride,cholesterol and leptin in serum increased significantly ( P <0 05 and P <0 01).The activity of GSH-Px increased and SOD decreased significantly ( P <0 05),the level of MDA increased,but there was no significant diference between two groups( P >0 05).Conclusion High energy diet induced obese rats to cause leptin resistance and the disorder of lipid metabolism,and made the activity of body antioxidation lower.