丹参多酚对慢性阻塞性肺疾病急性加重期肺动脉压及D-二聚体的影响 |
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引用本文: | 张双胜,胡紫光.丹参多酚对慢性阻塞性肺疾病急性加重期肺动脉压及D-二聚体的影响[J].中医临床研究,2014(4):24-25. |
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作者姓名: | 张双胜 胡紫光 |
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作者单位: | 江门市中心医院; |
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摘 要: | 目的:探讨丹参多酚注射液对慢性阻塞性肺疾病急性加重期肺动脉压及D-二聚体的影响。方法:40例符合诊断标准的AECOPD患者被随机分为对照组和治疗组,两组均接受COPD诊治指南推荐的抗感染、化痰、平喘、吸氧等治疗,治疗组在上述治疗的基础上与丹参多酚200mg/d,静脉滴注,两组疗程均为14d,治疗前后分别测定肺动脉压及D-二聚体,对其结果进行统计学分析。结果:治疗前两组AECOPD患者D-二聚体水平均高于正常参考值上限,治疗后两组肺动脉压及D-二聚体水平均有下降,其中治疗组上述指标下降更为显著,治疗前后比较P<0.05;治疗后组间比较亦有显著性差异P<0.05。结论:丹参多酚注射液可改善AECOPD患者血液高凝状态,改善机体氧合功能,降低肺动脉压,有助于提高临床疗效。
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关 键 词: | 慢性阻塞性肺疾病 急性加重期 肺动脉压 D-二聚体 |
Influence of salvianolate on AECOPD pulmonary artery pressure and D-dimer |
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Abstract: | Objective: To investigate the influence of salvianolate on COPD acute exacerbation pulmonary artery pressure and D-dimer. Methods: 40 patients with chronic obstructive pulmonary disease acute exacerbation (AECOPD) were randomly divided into control group and treated group. Both groups were accepted COPD treatment guidelines recommend anti-infection, phlegm, asthma, oxygen therapy etc. The treated group was given salvianolate 200mg/d, intravenous infusion more. The treatment lasted 14 days, before and after treatment pulmonary artery pressure and D-dimer were measured, the results were statistically analyzed. Results:Before treatment, patients with AECOPD D-dimer levels were higher than the upper limit of normal reference values, the two groups after the treatment pulmonary arterial pressure and D-dimer levels were decreased, in the treated group decreased more significantly above indicators, before and after treatment P〈0.05. Between the two groups showed significant differences P〈0.05. Conclusion:Salvianolate injection can improve AECOPD patients with hypercoagulable states, improve the body’s oxygenation and reduce pulmonary artery pressure, helps to improve the clinical efficacy. |
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Keywords: | COPD Acute exacerbation Pulmonary artery pressure D-dimer |
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