| 皮肤恶性肿瘤microRNA的研究进展 |
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| 引用本文： | 尹新江,何春涤.皮肤恶性肿瘤microRNA的研究进展[J].实用皮肤病学杂志,2014(3):204-206. |
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| 作者姓名： | 尹新江 何春涤 |
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| 作者单位： | 中国医科大学附属第一医院皮肤科,沈阳110001 |
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| 摘 要： | MicroRNA(miRNA)分子广泛参与调控机体细胞的增生、分化、代谢、凋亡等生理病理活动,通过各种复杂的机制调控肿瘤的发生和发展。近来研究发现,皮肤肿瘤中存在miRNA的异常表达,提示miRNA亦参与皮肤肿瘤的发生和发展过程,同时人们对二者的关系及其具体机制进行了研究。该文对基底细胞癌(basal cell carcinoma,BCC)、鳞状细胞癌(squamous cell carcinoma,SCC)、恶性黑素瘤(malignant melanoma,MM)miRNA研究进展作一概述。
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| 关 键 词： | 肿瘤 皮肤 癌 鳞状细胞 癌 基底细胞 黑素瘤 恶性 |
The study of microRNAs in skin cancer |
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| YIN Xin-jiang,HE Chun-di.The study of microRNAs in skin cancer[J].Journal of Practical Dermatology,2014(3):204-206. |
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| Authors: | YIN Xin-jiang HE Chun-di |
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| Institution: | ( Department of Dermatology, the First Hospital of China Medical University, Shenyang 110001, China) |
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| Abstract: | MicroRNA molecules are widely involved in regulation of physiological and pathological events such as cell proliferation, differentiation, metabolism and apoptosis, which regulates the tumorigenesis and development by a variety of complex mechanisms. Recent studies have found that there is abnormal miRNA expression in skin tumors, suggesting that miRNAs are also involved in skin tumor development process, meanwhile, the relationship between them and their speciifc mechanisms are studied. This article summarizes the current knowledge on miRNAs deregulation in three major skin cancer, including basal cell carcinoma （BCC）, squamous cell carcinoma （SCC） and malignant melanoma （MM）. |
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| Keywords: | microRNAs Tumors skin MicroRNAs Carcinoma basal cell Carcinoma squamous cell Malignant melanoma |
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