血脂康胶囊对db/db小鼠胰岛第一时相分泌及β细胞含量的影响 |
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引用本文: | 陆钟钰,蒋卫民,顾萍.血脂康胶囊对db/db小鼠胰岛第一时相分泌及β细胞含量的影响[J].中医临床研究,2014(5):3-5. |
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作者姓名: | 陆钟钰 蒋卫民 顾萍 |
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作者单位: | 南通市老年康复医院;江苏省中医院;南京军区南京总医院; |
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摘 要: | 目的:探讨血脂康胶囊对于db/db小鼠胰岛第一时相分泌及β细胞含量的影响。方法:选择40只12周龄清洁级雄性db/db小鼠,20只同周龄同窝出生的db/m小鼠,为非糖尿病对照组,将db/db小鼠随机分为血脂康组、安慰剂组,分别给予1次/d的血脂康胶囊0.3g/(kg·d)和安慰剂(5%阿拉伯胶)混悬液灌胃;db/m小鼠1次/d灌服同等体积的生理盐水。6周后采用离体胰岛灌流系统评估胰岛第一时相分泌,运用免疫组织化学及胰岛测量学分析胰岛β细胞含量。结果:治疗6周后血脂康组胰岛第一时相分泌得到显著改善,并可显著地减少了胰岛β细胞的丢失。结论:血脂康胶囊具有改善胰岛素第一时相分泌,保护β细胞功能等作用。
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关 键 词: | 血脂康胶囊 胰岛β细胞 胰岛素分泌 |
The effect of Xuezhikang on the islets of db/db mice first phase secretion and beta cell content |
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Abstract: | Objective:To investigate the effect of Xuezhikang on the islets of db/db mice first phase secretion and beta cell content. Methods: 40 male 12 weeks of age, clean level in db/db mice (congenital diabetic mice model), 20 with weeks of age, littermates db/m mice, non-diabetic control group, the db/db mice were divided into two groups, were given the Xuezhikang 0.3g/(kg·d) and placebo (5%gum arabic) suspension orally once a day;db/m mouse non-diabetic control group, an equal volume of saline once a day gavage. 6 weeks after the isolated islets perfusion system for evaluating the islet of first phase secretion, learning content of beta cell of islet using chemical measurement. Results: After 6 weeks of treatment, Xuezhikang group of islets first phase secretion to be improved can significantly reduce the loss of islet beta cells. Conclusion: Xuezhikang can improve the first phase insulin secretion, protect the beta cell function. |
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Keywords: | Xuezhikang Insulin resistance Lipid disorders |
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