自拟中药汤剂联合凯时治疗下肢动脉硬化闭塞症的临床分析

目的:拟通过观察自拟中药汤剂联合凯时(前列腺素E1)治疗下肢动脉硬化闭塞症(ASO)的临床疗效,探讨其可能的作用机制。方法:将入选的30例ASO患者随机分成两组,治疗组予自拟中药汤剂水煎服,1剂/d,配合凯时10μg/d,静点;对照组仅予凯时静点治疗。10d为1个疗程,3个疗程后进行疗效评定,同时观察治疗前后患者血液流变学、同型半胱氨酸(Hcy)的改变,应用动脉硬化检测仪分别观察治疗前和治疗后踝肱指数(ABI)及颈动脉-股动脉脉搏传导速度(PWV)等指标的改善情况等。结果:治疗组总有效率86.67%;对照组总有效率73.33%,两组比较有统计学意义(P<0.05)。与治疗前比较,治疗后血液流变学、Hcy、ABI、PWV均有改善;与对照组比较有统计学意义(P<0.05)。结论:中药汤剂联合凯时通过降低血液黏度,缓解高凝状态和通过改善动脉僵硬度,使血管获益达到治疗ASO的目的。

Clinical analysis on treating lower extremity arteriosclerosis obliterans by TCM combined with Kaishi

Objective： To investigate the mechanism of action on treating lower extremity arteriosclerosis obliterans by TCM combined with Kaishi （prostaglandin E1）. Methods：30 cases were randomly divided into two groups, in the treated group was treated by TCM, 1 agent/d, with Kay at 10μg/d, static point;the control group was treated by Kaishi. 10 days are 1 treatment course, after 3 courses of curative effect evaluation, to observe the changes of Blood rheology, homocysteine （Hcy） before and after treatment, and to observe the improve situation of the ankle brachial index （ABI） and carotid femoral pulse wave velocity （PWV） and other indicators by arteriosclerosis detector. Results：The treated group total efficiency 86.67%;control group total efficiency 73.33%, two groups was statistically significant （P〈0.05）. After treatment blood rheology, Hcy, ABI, PWV were improved; there was statistical significance compared with the control group （P〈0.05）. Conclusion： Treating lower extremity arteriosclerosis obliterans by TCM combined with Kaishi, by reducing the blood viscosity, relieve the hypercoagulability, through the improvement of arterial stiffness to the vascular benefits, achieve the purpose of treatment of ASO.