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Role of bovine mammillitis virus towards preparation of an alternative vaccine against herpes simplex virus infections of human subjects
Authors:G R Skinner  A Buchan  J Durham  M Cowan  J Davies  K Brookes  G Castrucci
Affiliation:1. Research Center for Aquatic Genomics, National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-8648, Japan;2. AXIOHELIX Co. Ltd., 5-11 Hakozaki, Nihonbashi, Chuouku 103-0015, Tokyo, Japan;3. Research Center for Subtropical Fisheries, Seikai National Fisheries Research Institute, 148-446 Fukai-Ohta, Ishigaki, Okinawa 907-0451, Japan;4. National Research Institute of Fisheries and Environmental of Inland Sea, 2-17-5 Maruishi, Ohno, Hatsukaichi, Hiroshima 739-0452, Japan;1. Yunnan Sugarcane Research Institute, Yunnan Academy of Agricultural Sciences. No. 363 East Lingquan Rd., Kaiyuan, Yunnan 661699, China;2. CSIRO Agriculture, Australian Tropical Science Innovation Precinct, Private Mail Bag, PO Aitkenvale, Townsville, QLD, 4814, Australia;3. Mackay Sugar Experiment Station, Sugar Research Australia, Peak Downs Highway, Te Kowai, PMB57, Mackay, Mail Centre, QLD, 4741, Australia;4. Yunnan Key Laboratory of Sugarcane Genetic Improvement, No. 363 East Lingquan Rd., Kaiyuan, Yunnan 661699, China
Abstract:Bovine mammillitis virus (BMV) cross-reacted in neutralization and radioimmune assay with herpes simplex virus (HSV) and pre-immunization with BMV protected against challenge by type 2 HSV. There was no evidence to suggest a pathogenic role for BMV as adjudged by a literature search or field enquiry and BMV specific antibody was not detected in 21 human sera or in four sera from personnel engaged in research with BMV; in addition there was no replication or antigen synthesis by BMV in explants of human tissue or cell lines of human origin. It is proposed that BMV might provide an alternative vaccine against HSV infections of human subjects.
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