| 药物的肠吸收与处置研究进展 |
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| 引用本文： | 林晓,徐德生,冯怡.药物的肠吸收与处置研究进展[J].中国临床药理学杂志,2004,20(1):72-75. |
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| 作者姓名： | 林晓 徐德生 冯怡 |
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| 作者单位： | 上海中医药大学,中药学院,上海201203 |
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| 摘 要： | 对近几年药物肠吸收与处置方面的研究进展进行了综述。包括:特定部位吸收、代谢的认识和利用,与药物首过效应有关的肠壁外泌及代谢作用的介绍,促进药物肠道吸收的方法及常用研究模型的比较。
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| 关 键 词： | 肠吸收 肠代谢 吸收促进剂 |
| 文章编号： | 1001-6821(2004)01-0072-04 |
Advance in search for intestinal absorption and disposition of drugs |
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| LIN Xiao,XU De-sheng,FENGYi.Advance in search for intestinal absorption and disposition of drugs[J].The Chinese Journal of Clinical Pharmacology,2004,20(1):72-75. |
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| Authors: | LIN Xiao XU De-sheng FENGYi |
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| Abstract: | This review focuses on advance in search for intestinal absorption and disposition of drugs, including cognition and utilization of special drag absorption site, introduction of drug gut wall metabolism, for example CYP3A4, and efflux by various cellular efflux pumps and transporters which related to first-pass drug elimination, the methods to enhance the intestinal absorption of drugs, comparison of several common transport models. |
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| Keywords: | intestinal absorption intestinal metabolism absorption enhancer |
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