右美托咪定抑制体外循环高血压的临床观察

目的观察应用右美托咪定预防体外循环(CPB)期间高血压的临床效果。方法择期行心脏二尖瓣+主动脉瓣双瓣膜置换手术患者40例,随机分为2组,每组20例。对照组(NS组):CPB开始后泵注生理盐水50 ml;右美托咪定组(M组):右美托咪定1μg/kg+生理盐水稀释50 ml,CPB开始后即刻泵注,30 min泵注完毕。观察两组患者CPB期间的平均动脉压(MAP)变化。结果 NS组发生高血压16例,M组2例;CPB开始后45 min、60 min、75 min时点的MAP,NS组明显高于M组(P<0.05)。结论右美托咪定能有效预防心脏手术CPB期间的高血压。

Precautionary effects of dexmedetomidin on hypertension during cardiopulmo-nary bypass

Objective To observe precautionary effects of dexmedetomidin on hypertension during cardiopulmonary bypass（ CPB）. Methods 40 patients undergoing mitral and aortic valve replacement（ double heart valve replacement） operation were randomly divided into two groups with 20 cases in each. The patients in control group（ NS group） were given normal saline while those in experimental group（ M group） were given dexmedetomidin 1 μg /kg in 30 min after CPB beginning. Mean arterial blood pressure（ MAP） was recorded during CPB. Results There were 16 cases occurred hypertension in NS group while 2 cases in M group.MAP at45 min,60 min,75 min after CPB beginning in NS group were significantly higher than those in M group（ P〈 0.01）. Conclusion Dexmedetomidi could prevent hypertension effectively during CPB in heart operation.