Neuropsychological profile of patients with juvenile myoclonic epilepsy: a controlled study of 50 patients |
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Authors: | Pascalicchio Tatiana Frascareli de Araujo Filho Gerardo M da Silva Noffs Maria Helena Lin Katia Caboclo Luís Otávio S F Vidal-Dourado Marcos Ferreira Guilhoto Laura M F Yacubian Elza Márcia Targas |
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Institution: | 1. Epilepsy Kempenhaeghe, Heeze, The Netherlands;2. Department of Neurology, Maastricht University Hospital, Maastricht, The Netherlands;3. Department of Neurology, Ghent University Hospital, Ghent, Belgium;4. Faculty of Electrical Engineering, University of Technology, Eindhoven, The Netherlands;1. Department of Psychology, Neuropsychology Section, St. Jude Children''s Research Hospital, Memphis, TN, USA;2. Jane and John Justin Neurosciences Center, Cook Children''s Medical Center, Fort Worth, TX, USA;1. Department of Psychology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada;2. Department of Psychology, University of Toronto Mississauga, Mississauga, Canada;3. Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada |
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Abstract: | The purpose of this study was to verify possible cognitive dysfunction in patients with juvenile myoclonic epilepsy (JME) and its relationship to factors related to epilepsy and schooling. Fifty subjects diagnosed with JME and 50 controls underwent neuropsychological assessment evaluating intellectual functions, attention, memory, executive functions, and language. The patients were further divided into two subgroups on the basis of educational level: < or = 11 and >11 years of formal education. Participants diagnosed with JME scored significantly below age-, education-, and gender-matched controls on neuropsychological measures of attention, immediate verbal memory, mental flexibility, control of inhibition, working memory, processing speed, verbal delayed memory, visual delayed memory, naming, and verbal fluency. A positive correlation was observed between duration of epilepsy and cognitive decline. However, in the group of patients with >11 years of education, this correlation was not significant. In this series of patients with JME, neuropsychological evaluation suggests widespread cognitive dysfunction outside the limits of the frontal lobes. The duration of epilepsy correlated with cognitive decline, and patients with higher education manifested less progression of deficits. |
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